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General: Head: Eyes: Joint & Muscle: Dermatological: Pain Headache Vision problems Joint Pain Rash Fatigue Facial pain Blurred vision Muscle pain Skin discoloration Weakness Migraine headaches Eye pain Swollen joints Easy bruising Weight loss Lightheadedness Sensitivity to light Joint stiffness Skin sores Fever Weakness in facial muscles Vision loss Muscle spasms Hives Swelling Nosebleeds Dry eyes Hip pain Itching Nausea Nasal congestion Red eyes Skin pigmentation loss Dizziness Double vision Movement / Reflexes: Redness Sleep problems Chest, Abdomen & Back: Watery eyes Stiffness Pale skin Malaise Shortness of breath Eyelid drooping Unsteady gait Butterfly-shaped rash Chills Abdominal pain Eye inflammation Involuntary movements Hyperpigmentation Abnormal lumps below skin Difficulty breathing Eye irritation Impaired coordination Dry skin Frequent infections Chest pain Blindness Paralysis Itchy skin Cramps Rapid Heartbeat Burning/gritty sensation in eyes Reduced reflexes Skin texture changes Night sweats Back pain Floaters in vision Blisters Coldness Irregular Heartbeat Neurological / Sensory: Yellow skin Weight gain Abdominal cramps Gastrointestinal: Seizures Hair loss Vertigo Heart palpitations Vomiting Tingling Tremor Diarrhea Numbness Cognitive / Mood: Limbs: Constipation Tenderness Memory problems Mouth & Throat: Bluish coloring of hands/feet Acid reflux/heartburn Burning Sensation Mood changes Difficulty swallowing Swollen feet Loss of bowel control Prickling sensations Psychosis Cough Foot pain Abdominal bloating Loss of sensation Personality changes Difficulty speaking Hand pain Hunger Sensitivity to extreme cold Behavioral changes Mouth ulcers Weakness in arms Blood in stool Sensory impairment Concentration loss Dry mouth Swollen hands Hearing loss Cognitive impairment Mouth sores Weakness in legs Reproductive Health: Ringing in ears Irritability Swelling in neck Swollen ankles Heavy menstrual flow Daytime sleepiness Depression Blister inside mouth Leg pain Infertility Anxiety Increased thirst Swollen legs Erectile dysfunction Urological: Confusion Sore throat Weakness in hands Pain during sexual intercourse Blood in urine Toe pain Dark urine Increased frequency of urination
Pain Fatigue Weakness Weight loss Fever Swelling Nausea Dizziness Sleep problems Malaise Chills Abnormal lumps below skin Frequent infections Cramps Night sweats Coldness Weight gain Vertigo Tremor Headache Facial pain Migraine headaches Lightheadedness Weakness in facial muscles Nosebleeds Nasal congestion Vision problems Blurred vision Eye pain Sensitivity to light Vision loss Dry eyes Red eyes Double vision Watery eyes Eyelid drooping Eye inflammation Eye irritation Blindness Burning/gritty sensation in eyes Floaters in vision Joint Pain Muscle pain Swollen joints Joint stiffness Muscle spasms Hip pain Rash Skin discoloration Easy bruising Skin sores Hives Itching Skin pigmentation loss Redness Pale skin Butterfly-shaped rash Hyperpigmentation Dry skin Itchy skin Skin texture changes Blisters Yellow skin Hair loss Stiffness Unsteady gait Involuntary movements Impaired coordination Paralysis Reduced reflexes Shortness of breath Abdominal pain Difficulty breathing Chest pain Rapid Heartbeat Back pain Irregular Heartbeat Abdominal cramps Heart palpitations Seizures Tingling Numbness Tenderness Burning Sensation Prickling sensations Loss of sensation Sensitivity to extreme cold Sensory impairment Hearing loss Ringing in ears Daytime sleepiness Vomiting Diarrhea Constipation Acid reflux/heartburn Loss of bowel control Abdominal bloating Hunger Blood in stool Memory problems Mood changes Psychosis Personality changes Behavioral changes Concentration loss Cognitive impairment Irritability Depression Anxiety Confusion Bluish coloring of hands/feet Swollen feet Foot pain Hand pain Weakness in arms Swollen hands Weakness in legs Swollen ankles Leg pain Swollen legs Weakness in hands Toe pain Difficulty swallowing Cough Difficulty speaking Mouth ulcers Dry mouth Mouth sores Swelling in neck Blister inside mouth Increased thirst Sore throat Heavy menstrual flow Infertility Erectile dysfunction Pain during sexual intercourse Blood in urine Dark urine Increased frequency of urination

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Category	Disease	Age of Onset	Female/ Male ratio	Level of Evidence[Reset]	US Prevalence (%)	US Cases Min	US Cases Max
Skin	Acquired epidermolysis bullosa	25-75	1.0x	Antibody	0.00%	27	167
Skin	Autoimmune Epidermolysis bullosa (synonym)	25-75	1.0x	Antibody	0.00%	27	167
Skin	Epidermolysis bullosa acquisita (synonym)	25-75	1.0x	Antibody	0.00%	27	167
Blood	Acquired hemophilia	After 65	Unknown	Antibody	0.00%	500	500
Blood	Acquired haemophilia (synonym)	After 65	Not established	Antibody	0.00%	500	500
Nervous System	Acute disseminated encephalomyelitis	30-40	4.5x	Antibody	0.00%	233	2,000
Nervous System	Hurst's disease (synonym)	30-40	4.5x	Antibody	0.00%	233	2,000
Nervous System	Nonvasculitic autoimmune inflammatory meningoencephalitis (synonym)	30-40	4.5x	Antibody	0.00%	233	2,000
Nervous System	Weston-Hurst syndrome (synonym)	30-40	4.5x	Antibody	0.00%	233	2,000
Nervous System	Acute hemorrhagic leukoencephalitis (subtype)	30-40	4.5x	Antibody	0.00%	233	2,000
Vascular system	Acute febrile mucocutaneous lymph node syndrome	Before 5	5.0x	Antibody	0.03%	116,322	116,322
Vascular system	Kawasaki Syndrome (synonym)	Before 5	5.0x	Antibody	0.03%	116,322	116,322
Vascular system	Kawasaki's disease (synonym)	Before 5	5.0x	Antibody	0.03%	116,322	116,322
Vascular system	Lymph Node Syndrome (synonym)	Before 5	5.0x	Antibody	0.03%	116,322	116,322
Vascular system	Mucocutaneous Lymph Node Syndrome (synonym)	Before 5	5.0x	Antibody	0.03%	116,322	116,322
Skin	Acute lichenoid pityriasis	Before 30	1.9x	Unconfirmed	0.03%	101,730	101,730
Skin	Acuta guttale parapsoriasis (synonym)	Before 30	1.9x	Unconfirmed	0.03%	101,730	101,730
Skin	Mucha-Habermann disease (synonym)	Before 30	1.9x	Unconfirmed	0.03%	101,730	101,730
Skin	Pityriasis lichenoides et varioliformis acuta (synonym)	Before 30	1.9x	Unconfirmed	0.03%	101,730	101,730
Glands	Addison's disease	40	8.6x	Antibody	0.01%	13,899	73,659
Glands	Adrenal Insufficiency (synonym)	40	8.6x	Antibody	0.01%	13,899	73,659
Glands	Autoimmune adrenalitis (synonym)	40	8.6x	Antibody	0.01%	13,899	73,659
Systemic	Adult onset Still's disease	20-45	9.0x	Antibody	0.00%	333	3,333
Systemic	Adult Still's disease (synonym)	20-45	9.0x	Antibody	0.00%	333	3,333
Nervous System	Age related macular degeneration	After 50	1.3x	Unconfirmed	6.25%	16,759,857	24,895,710
Skin	Alopecia areata	Before 30	2.9x	Antibody	0.21%	699,930	699,930
Skin	Alopecia Totalis (subtype)	Before 30	2.9x	Antibody	0.21%	699,930	699,930
Skin	Alopecia Universalis (subtype)	Before 30	2.9x	Antibody	0.21%	699,930	699,930
Systemic	Angiofollicular lymph node hyperplasia	Any age	Unknown	Antibody	0.00%	1,233	4,433
Systemic	Castleman Disease (synonym)	Any age	Not established	Antibody	0.00%	1,233	4,433
Systemic	Castleman's disease (synonym)	Any age	Not established	Antibody	0.00%	1,233	4,433
Musculoskeletal	Ankylosing spondylitis	20-45	1.1x	Unconfirmed	0.26%	866,580	866,580
Musculoskeletal	Axial spondyloarthritis (synonym)	20-45	1.1x	Unconfirmed	0.26%	866,580	866,580
Musculoskeletal	Spondyloarthritis (synonym)	20-45	1.1x	Unconfirmed	0.26%	866,580	866,580
Kidney	Anti-glomerular basement membrane disease	20-30	Unknown	Antibody	0.00%	333	333
Kidney	Anti-GBM disease (synonym)	20-30	Not established	Antibody	0.00%	333	333
Kidney	Anti-glomerular basement membrane tubulointerstitial nephritis (synonym)	20-30	Not established	Antibody	0.00%	333	333
Kidney	Goodpasture disease (synonym)	20-30	Not established	Antibody	0.00%	333	333
Kidney	Goodpasture syndrome (synonym)	20-30	Not established	Antibody	0.00%	333	333
Kidney	Goodpasture's disease (synonym)	20-30	Not established	Antibody	0.00%	333	333