The Autoimmune Registry
Pure red cell aplasia Insufficent data to report on this disease.
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  • Names
    • Pure red cell aplasia
    • Acquired pure red cell aplasia
    • Adult pure red cell aplasia
    • Idiopathic pure red cell aplasia
    • Primary acquired PRCA
    • Primary acquired pure red cell aplasia
    Abbreviations: PRCA
    Category: Blood
    Prevalence No data on US prevalence. No studies found. Female/Male ratio: Unknown.
    Age of Onset No data.
    Description Pure red cell aplasia (PRCA) occurs when red blood cells fail to fully develop after they are produced in the bone marrow. This leads to symptoms of anemia, including tiredness and pale skin. There are 2 types of PRCA caused by autoimmune processes:

    Acquired primary PRCA typically affects adults and leads to symptoms of anemia. The trigger for primary PRCA is unknown. Acquired primary PRCA is caused by the immune system attacking developing red blood cells, preventing them from maturing into functional adult cells.

    Acquired secondary PRCA, which is also autoimmune, is similar to acquired primary PRCA but the trigger is an infection, another autoimmune disorder, pregnancy, drugs, or cancer. PRCA is also one of the important complications in hematopoietic stem cell transplantation when the blood type of the donor and recipient do not match.

    Patients may experience symptoms of anemia as well as symptoms of the underlying health condition. Treatments for both primary and secondary PRCA are available, but outcomes vary, and life expectancy is often markedly reduced.

    A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and presents during infancy. It is not autoimmune.

    Evidence of autoimmunity: Antibody
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      Resources Link to Clinical Trials
      Link to PubMed
      References Link to Mayo Clinic
      Link to Cleveland Clinic
      Link to Healthline
      Profile by: Jalin Armstead
    • Profile updated September 2024
    • Charts generated Oct 12, 2024 at 12:54 PM ET
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    • Pure red cell aplasia top comorbidities/symptoms
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      * Disease is suspected as autoimmune, but unconfirmed.
      Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.

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      Pure red cell aplasia top immunosuppressants / autoimmune therapies


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      * Biologic medications.
      Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

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      Patient-reported 7-day average pain
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      Patient-reported 7-day average fatigue
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      General physical health
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      General mental health
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      Social and relationship satisfaction
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      General quality of life
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      Ability to carry out social roles and activities
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      Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

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      Concerns about ability to pay
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      Feeling unheard by healthcare providers
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      Patient employment status
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      Patient insurance coverage
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      Insufficent data to report on this disease.