The Autoimmune Registry
Ophthalmoplegia due to Graves' disease Graphs for this disease are generated based on data from the Autoimmune Registry Inc.
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  • Names
    • Ophthalmoplegia due to Graves' disease
    • Graves' eye disease
    • Graves ophthalmopathy
    • Graves' ophthalmopathy
    • Graves' orbitopathy Graves' eye disease
    • Thyroid eye disease
    • Thyroid-Associated orbitopathy

    Category: Nervous System
    Prevalence No data on US prevalence. Female/Male ratio: 12.0x.
    Age of Onset Onset typically occurs between ages 20 and 50.
    Description Graves’ ophthalmopathy (GO) is an autoimmune disorder affecting the eyes that is associated with Graves’ disease. In Graves’ disease, the immune system targets and damages a specific cell type found in the thyroid. This cell type is also found in the tissues surrounding the eyes (the orbit), and Graves’ ophthalmopathy results when the immune system attacks these orbital cells in addition to the cells in the thyroid.

    Patients with GO experience swelling in the tissues, muscles, and fat in the eye socket, which leads to an abnormal protrusion of the eye. Smoking is associated with a greater risk of acquiring GO. Patients often experience full recovery without intervention, but treatments are available to manage symptoms.

    Evidence of autoimmunity: Antibody
    Patient Groups
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      Symptoms   
      Resources Link to Clinical Trials
      Link to PubMed
      References Link to Mayo Clinic
      Link to Cleveland Clinic
      Link to Healthline
      Profile by: Emily Romanello
    • Profile updated September 2024
    • Charts generated Oct 12, 2024 at 12:54 PM ET
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      Ophthalmoplegia due to Graves' disease sex breakdown


      Ophthalmoplegia due to Graves' disease age breakdown

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      Graphs for this disease are generated based on data from the Autoimmune Registry Inc.

    • Ophthalmoplegia due to Graves' disease top comorbidities/symptoms
      Chart is omitted due to low report count.

      Ophthalmoplegia due to Graves' disease top autoimmune comorbidities


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      * Disease is suspected as autoimmune, but unconfirmed.
      Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.


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      * Biologic medications.
      Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

    • Quick links: 
      Quick Links

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      Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

    • Quick links: 
      Quick Links

      Join the registry!

      Graphs for this disease are generated based on data from the Autoimmune Registry Inc.