The Autoimmune Registry
Mixed collagen vascular disease Graphs for this disease are generated based on data from the Autoimmune Registry Inc.
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  • Names
    • Mixed collagen vascular disease
    • Mixed connective tissue disease
    • Sharp Syndrome
    Abbreviations: MCTD
    Category: Systemic
    Prevalence From 8,297 to 11,409 cases in the US (Gunnarsson 2011). Female/Male ratio: 32.1x.
    Age of Onset Onset typically occurs between ages 15 and 25.
    Description Mixed collagen vascular disease, also called mixed connective tissue disease (MCTD), is an autoimmune disorder that shares symptoms with other connective tissue diseases, including polymyositis/dermatomyositis, systemic lupus erythematosus (SLE), scleroderma, and autoimmune rheumatic diseases. Examples of commonly shared symptoms are abnormally cold hands, joint pain, organ problems, and feelings of malaise. However, one feature unique to MCTD is the presence of anti-RNP antibodies in the blood. Raynaud's phenomenon and high blood pressure in the lungs are also more common in MCTD, while kidney symptoms are milder. Some complications can be fatal, but treatments are available to manage both mild and life-threatening symptoms. [Hajas et al., 2013].

    Evidence of autoimmunity: Antibody
    Patient Groups
    Bloggers
    Symptoms
    Resources Link to Clinical Trials
    Link to PubMed
    References Link to Mayo Clinic
    Link to Cleveland Clinic
    Link to Healthline
    Profile by: Emily Romanello
  • Profile updated September 2024
  • Charts generated Oct 12, 2024 at 12:54 PM ET
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    Mixed collagen vascular disease sex breakdown


    Mixed collagen vascular disease age breakdown

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    Graphs for this disease are generated based on data from the Autoimmune Registry Inc.

  • Mixed collagen vascular disease top comorbidities/symptoms
    Chart is omitted due to low report count.

    Mixed collagen vascular disease top autoimmune comorbidities


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    * Disease is suspected as autoimmune, but unconfirmed.
    Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.

  • Anti-inflammatory / specialty medications and supplements

    Mixed collagen vascular disease top immunosuppressants / autoimmune therapies


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    * Biologic medications.
    Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Quick links: 
    Quick Links

    Patient-reported 7-day average pain
    Chart is omitted due to low report count.


    Patient-reported 7-day average fatigue
    Chart is omitted due to low report count.


    General physical health
    Chart is omitted due to low report count.


    General mental health
    Chart is omitted due to low report count.


    Social and relationship satisfaction
    Chart is omitted due to low report count.


    General quality of life
    Chart is omitted due to low report count.


    Ability to carry out social roles and activities
    Chart is omitted due to low report count.


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    Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Quick links: 
    Quick Links

    Concerns about ability to pay
    Chart is omitted due to low report count.


    Feeling unheard by healthcare providers
    Chart is omitted due to low report count.


    Patient employment status
    Chart is omitted due to low report count.


    Patient insurance coverage
    Chart is omitted due to low report count.


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    Graphs for this disease are generated based on data from the Autoimmune Registry Inc.