The Autoimmune Registry

Disease Profile

Names	Ligneous conjunctivitis Adult Onset Ligneous conjunctivitis Autoimmune ligneous conjunctivitis Conjunctivitis lignose Category: Nervous System
Prevalence	Extremely rare. Fewer than 100 cases in the US. No studies found. Female/Male ratio: Unknown.
Age of Onset	No data.
Description	Ligneous conjunctivitis is a rare, chronic form of conjunctivitis that starts in adulthood. A genetically caused form of the disease can occur in childhood, but these cases are not autoimmune. Patients with ligneous conjunctivitis have large, inflamed, woody growths on the inside of the eyelid and potentially whites of the eye. These growths may also occur in the mouth, ears, respiratory tract, and genitourinary tract. The inflamed growths are likely to come back after they have been removed. If untreated, ligneous conjunctivitis can lead to vision loss and sometimes life-threatening pulmonary complications. Not confirmed as an autoimmune or autoinflammatory disease. ICD-10 Code: H10.51 SNOMED Code: 403435005
Patient Groups	Click here to tell us about a non-profit that advocates for Ligneous conjunctivitis. (Non-profit)
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Symptoms	PainEar painFrequent infectionsMouth ulcersHearing lossWatery eyesSore throatRed eyesChange in voiceEye dischargeSores or masses under eyelidEye painEye lesionsSensitivity to lightEye irritationThickening of eyelid mucosa with a wood-like consistencyGum enlargementFeverLoss of teeth
Resources	Link to Clinical Trials Link to PubMed
References	Link to Mayo Clinic Link to Cleveland Clinic Link to Healthline
	Profile by: Spencer Schulman Profile updated September 2024 Charts generated Oct 12, 2024 at 12:54 PM ET

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* Disease is suspected as autoimmune, but unconfirmed.
Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.
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* Biologic medications.
Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
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Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
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Insufficent data to report on this disease.