| Names |
- Juvenile Rheumatoid Arthritis
- Juvenile Chronic Arthritis
- Juvenile idiopathic arthritis
- Pediatric rheumatic disease
Abbreviations: JIA, JRA
Category: Musculoskeletal |
| Prevalence |
From 28,934 to 37,148 cases in the US (Harrold 2017). Female/Male ratio: 3.7x. |
| Age of Onset |
Onset typically before 16 years old. |
| Description |
Juvenile rheumatoid arthritis is a pediatric disorder affecting the joints. Damage occurs when immune cells penetrate the lining of the joints, causing inflammation. Patients typically experience joint pain and swelling, which may occur in a flare/remission pattern. Some subtypes have strong evidence of being autoimmune. The condition is diagnosed through exclusion, when joint inflammation lasts more than 6 weeks in a patient 16 years-old or younger and cannot be positively diagnosed with another condition.
There are 7 types of juvenile arthritis:
1. Systemic juvenile idiopathic arthritis occurs in at least one joint accompanied by fever for 2 weeks or longer. Other possible symptoms include rash or enlargement of the lymph nodes, liver, or spleen.
2. Oligoarticular juvenile arthritis (oligoarthritis) occurs in not more than 4 joints in the 6 months following disease onset. After this point, the condition may remain stable (persistent oligoarthritis), or it may spread to additional joints (extended oligoarthritis). The eyes may also be affected.
3. Rheumatoid factor positive polyarticular juvenile idiopathic arthritis (polyarthritis and rheumatoid factor positive are alternative terms) has symptoms similar to adult rheumatoid arthritis but occurs in children. Patients typically experience arthritis in a minimum of 5 joints in the 6 months following disease onset. Blood tests reveal the presence of rheumatoid factors, a type of autoimmune antibody. The evidence suggests strongly that this subtype is autoimmune.
4. Rheumatoid factor negative polyarticular juvenile idiopathic arthritis (polyarthritis and rheumatoid factor negative are alternative terms) is marked by the same symptoms as patients with rheumatoid factor positive. The negative variety is distinguished from the positive variety by an absence of rheumatoid factors in the blood.
5. Psoriatic juvenile idiopathic arthritis causes both arthritis and red skin rashes with white scaling (psoriasis). Irregularities in the fingers, nails, or eyes may also occur.
6. Enthesitis-related juvenile idiopathic arthritis causes discomfort where the bone joins with other tissues, such as tendons and ligaments. Irritation is frequent in the hips, knees, and feet. Tissue besides the joints may also become inflamed.
7. Undifferentiated arthritis describes patients whose symptoms are not compatible with the other 6 categories of juvenile arthritis, or whose presentation includes symptoms from multiple categories.
Some patients experience full relief from symptoms with medical attention, while others experience relapses throughout life. Treatments are available to control symptoms and improve function.
Evidence of autoimmunity: Antibody
ICD-10 Code: M08.0 SNOMED Code: 410795001
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| Symptoms |
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| Resources |
Link to Clinical Trials
Link to PubMed |
| References |
Link to Mayo Clinic
Link to Cleveland Clinic
Link to Healthline
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Profile by: Emily RomanelloProfile updated September 2024Charts generated Oct 12, 2024 at 12:54 PM ET |
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Juvenile Rheumatoid Arthritis sex breakdown
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Juvenile Rheumatoid Arthritis age breakdown
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Patient ethnicities
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