The Autoimmune Registry
Cold agglutinin disease Graphs for this disease are generated based on data from the Autoimmune Registry Inc.
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  • Names
    • Cold agglutinin disease
    • Anemia, hemolytic cold antibody
    • Cold antibody disease
    • Cold autoimmune hemolytic anemia
    Abbreviations: CAD
    Category: Blood
    Prevalence 5,399 cases in the US (Mullins 2017). Female/Male ratio: 8.7x.
    Age of Onset Onset typically occurs between ages 60 and 70.
    Description Cold agglutinin disease is a type of autoimmune hemolytic anemia in which the body's immune system attacks and destroys its own red blood cells. Unlike warm autoimmune hemolytic anemia, the autoimmune destruction of cells occurs when a person is exposed to cold, or their body temperature is below normal. Some patients experience heart problems because the heart has to work harder to make sure the body gets enough healthy red blood cells

    Evidence of autoimmunity: Antibody
    ICD-10 Code: D59.12     SNOMED Code: 398937006
    Patient Groups
    Bloggers
    Symptoms
    Resources Link to Clinical Trials
    Link to PubMed
    References Link to Mayo Clinic
    Link to Cleveland Clinic
    Link to Healthline
    Profile by: Candace Marks
  • Profile updated September 2024
  • Charts generated Oct 12, 2024 at 12:54 PM ET
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    Cold agglutinin disease sex breakdown


    Cold agglutinin disease age breakdown

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    Graphs for this disease are generated based on data from the Autoimmune Registry Inc.

  • Cold agglutinin disease top comorbidities/symptoms
    Chart is omitted due to low report count.

    Cold agglutinin disease top autoimmune comorbidities


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    * Disease is suspected as autoimmune, but unconfirmed.
    Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.

  • Anti-inflammatory / specialty medications and supplements


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    * Biologic medications.
    Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Quick links: 
    Quick Links

    Patient-reported 7-day average pain
    Chart is omitted due to low report count.


    Patient-reported 7-day average fatigue
    Chart is omitted due to low report count.


    General physical health
    Chart is omitted due to low report count.


    General mental health
    Chart is omitted due to low report count.


    Social and relationship satisfaction
    Chart is omitted due to low report count.


    General quality of life
    Chart is omitted due to low report count.


    Ability to carry out social roles and activities
    Chart is omitted due to low report count.


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    Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Quick links: 
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    Concerns about ability to pay
    Chart is omitted due to low report count.


    Feeling unheard by healthcare providers
    Chart is omitted due to low report count.


    Patient employment status
    Chart is omitted due to low report count.


    Patient insurance coverage
    Chart is omitted due to low report count.


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    Graphs for this disease are generated based on data from the Autoimmune Registry Inc.