The Autoimmune Registry

Disease Profile

Names	Autoimmune orchitis Category: Glands
Prevalence	Extremely rare. Fewer than 100 cases in the US. No studies found. Female/Male ratio: Unknown.
Age of Onset	No data.
Description	Autoimmune orchitis involves inflammation of the testicles and the presence of specific antibodies against sperm. There are two types of this condition: primary autoimmune orchitis and secondary autoimmune orchitis. Primary autoimmune orchitis is found in men who are infertile and have no symptoms of other diseases. It is characterized by inflammation in the testicles and the presence of antibodies targeting the structures in the testicles. Men with this condition do not have any systemic illnesses and usually show no symptoms. Secondary autoimmune orchitis occurs in men with a systemic autoimmune disease, especially those with conditions like vasculitis. About 50% of these patients have antibodies against sperm, with systemic lupus erythematosus being a common related condition. The exact cause of both primary and secondary autoimmune orchitis is still unknown, but it is believed to be due to a combination of factors. Inflammation, infection, or injury to the testicles may trigger an immune response, leading to the production of antibodies against sperm. These antibodies can cause sperm to clump together or become immobilized, preventing them from fertilizing an egg and leading to infertility. Evidence of autoimmunity: Antibody
Patient Groups	Click here to tell us about a non-profit that advocates for autoimmune orchitis. (Non-profit)
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Symptoms	PainFeverSwellingNauseaTesticle painVomitingSwollen testiclesMalaise
Resources	Link to Clinical Trials Link to PubMed
References	Link to Mayo Clinic Link to Cleveland Clinic Link to Healthline
	Profile by: Lauren Young Profile updated June 2024 Charts generated Oct 12, 2024 at 12:54 PM ET

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* Disease is suspected as autoimmune, but unconfirmed.
Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.
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* Biologic medications.
Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
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Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
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Insufficent data to report on this disease.