The Autoimmune Registry
Anti-glomerular basement membrane disease Graphs for this disease are generated based on data from the Autoimmune Registry Inc.
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  • Names
    • Anti-glomerular basement membrane disease
    • Anti-GBM disease
    • Anti-glomerular basement membrane tubulointerstitial nephritis
    • Goodpasture disease
    • Goodpasture syndrome
    • Goodpasture's disease
    • Goodpasture's syndrome

    Category: Kidney
    Incidence 333 cases in the US per year (Lingaraj 2017). Female/Male ratio: Unknown.
    Age of Onset Onset typically occurs between ages 20 and 30.
    Description Anti-glomerular basement membrane disease (anti-GBM disease) is a rare condition characterized by rapidly deteriorating kidney function and lung tissues. It stems from an autoimmune reaction, where the body's immune system erroneously targets and destroys healthy tissues. Individuals afflicted with this ailment produce antibodies that assail a protein known as collagen within the lung's small air sacs and the kidney's glomeruli, which are its filtering units. These antibodies, termed anti-glomerular basement membrane antibodies, can inflict harm upon the basement membrane, leading to kidney impairment. Occasionally, the onset of this disorder is precipitated by a viral respiratory infection or exposure to hydrocarbon solvents. In such instances, the immune system may misinterpret organs or tissues as foreign agents, prompting an attack. Consequently, this flawed immune response results in lung air sac bleeding and inflammation within the kidney's filtering units.

    Evidence of autoimmunity: Antibody
    Patient Groups
    Bloggers
      Symptoms
      Resources Link to Clinical Trials
      Link to PubMed
      References Link to Mayo Clinic
      Link to Cleveland Clinic
      Link to Healthline
      Profile by: Laavanya Pasupuleti
    • Profile updated March 2024
    • Charts generated Oct 12, 2024 at 12:54 PM ET
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      Anti-glomerular basement membrane disease sex breakdown


      Anti-glomerular basement membrane disease age breakdown

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      Graphs for this disease are generated based on data from the Autoimmune Registry Inc.

    • Anti-glomerular basement membrane disease top comorbidities/symptoms
      Chart is omitted due to low report count.

      Anti-glomerular basement membrane disease top autoimmune comorbidities


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      * Disease is suspected as autoimmune, but unconfirmed.
      Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.

    • Anti-inflammatory / specialty medications and supplements


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      * Biologic medications.
      Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

    • Quick links: 
      Quick Links

      Patient-reported 7-day average pain
      Chart is omitted due to low report count.


      Patient-reported 7-day average fatigue
      Chart is omitted due to low report count.


      General physical health
      Chart is omitted due to low report count.


      General mental health
      Chart is omitted due to low report count.


      Social and relationship satisfaction
      Chart is omitted due to low report count.


      General quality of life
      Chart is omitted due to low report count.


      Ability to carry out social roles and activities
      Chart is omitted due to low report count.


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      Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

    • Quick links: 
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      Concerns about ability to pay
      Chart is omitted due to low report count.


      Patient employment status
      Chart is omitted due to low report count.


      Patient insurance coverage
      Chart is omitted due to low report count.


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      Graphs for this disease are generated based on data from the Autoimmune Registry Inc.