The Autoimmune Registry

Acquired epidermolysis bullosa

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Disease Profile Top Comorbidities

Names	Acquired epidermolysis bullosa Autoimmune Epidermolysis bullosa Epidermolysis bullosa acquisita Abbreviations: EBA Category: Skin
Incidence	From 26 to 166 cases in the US per year (Iranzo 2014). Female/Male ratio: 1.0x.
Age of Onset	Onset typically occurs between ages 25 and 75.
Description	In epidermolysis bullosa acquisita (EBA) the skin and mucus membranes are chronically inflamed and may form blisters in response to minor injury. Common areas of blistering include the hands, feet, knees, elbows, and buttocks. It can also affect the mouth, nose, and eyes. Evidence suggests an association between EBA and inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease. IBD is reported to be present in approximately 30% of EBA patients. There are two main types of EBA, non-inflammatory and non-inflammatory. The non-inflammatory type is more common and resembles the hereditary disease, epidermolysis bullosa. The inflammatory types resemble autoimmune bullous pemphigoid. Mucous Membrane EBA (MM-EBA) is a type of inflammatory EBA that affects mucous membranes. EBA is marked by the presence of autoantibodies (mainly IgG class) to type VII collagen (Col7). EBA may mimic other inflammatory blistering diseases, most often bullous pemphigoid and bullous systemic lupus erythematosus (which is also associated with anti-Col7 autoantibodies). Evidence of autoimmunity: Antibody ICD-10 Code: L12.3 SNOMED Code: 2772003
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Symptoms	BlistersWidespread redness and itchingInvolves mucous membranesEba symptoms may mimic bullous pemphigoid and bullous systemic lupus erythematosusHealing with minimal scarring Non-inflammatory eba: Mucous membrane eba:Tense, blood- or pus-filled blisters, mostly on the hands, knees, knuckles, elbows and anklesBlisters on various mucous membranesMucous-membrane blisters that rupture easilyScarringWhen blisters heal they form scars and sometimes tiny white bumps In comparison to bullous pemphigoid, eba: Inflammatory eba:Arises in younger individuals, usually under the age of 70 yearsWidespread blisters that are not localized to trauma-prone sitesHas prominent involvement of the head and neck
Resources	Link to Clinical Trials Link to PubMed
References	Link to Mayo Clinic Link to Cleveland Clinic Link to Healthline
	Profile by: Autoimmune Registry Profile updated September 2024 Charts generated Oct 12, 2024 at 12:54 PM ET

Acquired epidermolysis bullosa sex breakdown

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Acquired epidermolysis bullosa age breakdown

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Graphs for this disease are generated based on data from the Autoimmune Registry Inc.

Acquired epidermolysis bullosa top comorbidities/symptoms
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Acquired epidermolysis bullosa top autoimmune comorbidities

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* Disease is suspected as autoimmune, but unconfirmed.
Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.
Anti-inflammatory / specialty medications and supplements

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* Biologic medications.
Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
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Patient-reported 7-day average pain
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Patient-reported 7-day average fatigue
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General physical health
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General mental health
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Social and relationship satisfaction
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General quality of life
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Ability to carry out social roles and activities
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Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
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Concerns about ability to pay
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Patient employment status
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Patient insurance coverage
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Graphs for this disease are generated based on data from the Autoimmune Registry Inc.